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| Depression |  |
Selective Serotonin Reuptake Inhibitors (SSRIs)
The group of antidepressants most frequently prescribed today are drugs that regulate the neurochemical serotonin. These are commonly known as selective serotonin reuptake inhibitors (SSRIs). They treat depression by "selectively" inhibiting the reuptake of serotonin. That means that, unlike TCAs, they are unlikely to block the cholinergic receptors in the brain. One of the main attraction of SSRIs is that they treat depression without the adverse effects of other antidepressants, such as the dry mouth caused by TCAs or the dietary restrictions mandated by MAOIs
Examples of SSRIs are: fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
Side Effects of SSRIs
 | Anxiety or nervousness |
| Gastrointestinal distress (nausea and diarrhea) |
| Headache |
| Insomnia |
| Rash |
| Slight weight loss |
| Sexual impotence in men (about 10%) |
| Lose of interest in sex for both men and women; inability to achieve orgasm |
Prozac has been known to trigger manic episodes in people with a personal and/or family history of bipolar disorder. Some people report having suicidal thoughts while taking Prozac.
SSRI-Drug Interactions
A list of potential SSRI interaction with other antidepressants and other drugs can be found in: Drug Interaction Guide For SSRI Antidepressants
Other Effects of Prozac
Prozac has acquired a folk reputation for helping people overcome not only their basic depressive symptoms but other conditions, such as:
| Overeating |
| Obsessive compulsive disorder |
| Excessive sensitivity to criticism |
| Fear of rejection |
| Lack of self-esteem |
| Limited ability to experience pleasure |
See Also:
Drug Interaction Guide For SSRI Antidepressants
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